The 27 Enzymes of Purine Metabolism

Enzyme names are derived from the name of the enzyme substrate, the type of reaction catalyzed, and the suffix "-ase." The 27 enzymes of purine metabolism are:

1. PRPP synthetase
2. PRPP amidotransferase
3. PRGA synthetase
4. PRGA formyltransferase
5. PRFGAN synthetase
6. PRAI synthetase
7. RAI carboxylase
8. SAICAR synthetase
9. Adenolosuccinate lyase
10. AICAR transformylase
11. Adenolosuccinate synthetase
12. Adenylosuccinate lyase
13. AMP deaminase
14. AMP kinase
15. Dinucleotide kinase
16. IMP dehydrogenase
17. GMP synthetase
18. GMP reductase
19. GMP kinase
20. Adenine phosphoribosyltransferase (APRT)
21. Hypoxanthine phosphoribosyltransferase (HPRT)
22. Adenosine kinase
23. 5' Nucleotidase
24. Adenosine deaminase (ADA)
25. Purine nucleoside phosphorylase (PNP)
26. Guanase
27. Xanthine oxidase

Reaction Pathways

• Reactions 1-10: the synthetic pathways
• Reactions 11-19: the conversion pathways
• Reactions 20-22: the reuse pathways
• Reactions 23-27: the disposal pathways

 Return to Figure 2