The 27 Enzymes of Purine Metabolism

Enzyme names are derived from the name of the enzyme substrate, the type of reaction catalyzed, and the suffix "-ase." The 27 enzymes of purine metabolism are:

  1. PRPP synthetase
  2. PRPP amidotransferase
  3. PRGA synthetase
  4. PRGA formyltransferase
  5. PRFGAN synthetase
  6. PRAI synthetase
  7. RAI carboxylase
  8. SAICAR synthetase
  9. Adenolosuccinate lyase
  10. AICAR transformylase
  11. Adenolosuccinate synthetase
  12. Adenylosuccinate lyase
  13. AMP deaminase
  14. AMP kinase
  15. Dinucleotide kinase
  16. IMP dehydrogenase
  17. GMP synthetase
  18. GMP reductase
  19. GMP kinase
  20. Adenine phosphoribosyltransferase (APRT)
  21. Hypoxanthine phosphoribosyltransferase (HPRT)
  22. Adenosine kinase
  23. 5' Nucleotidase
  24. Adenosine deaminase (ADA)
  25. Purine nucleoside phosphorylase (PNP)
  26. Guanase
  27. Xanthine oxidase

 

Reaction Pathways

 

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